synthesis of aspirin equation

2%. This way an idea of the safety conditions and the handling of chemicals can be considered. Look carefully at the aspirin in the small test tube. stream Mass is measured in grams ? madehow. The synthesis of aspirin is classified as an esterification reaction. These can be found under the hypothesis subheading. N-acyliminium is a better electrophile than acetic anhydride due to the withdrawal of electron density from the electrophilic carbon by the nitrogen of the pyridyl ring. Overall this shows that the experiment was a success as a large amount of aspirin was produced, however these results also showed that there was major errors or inefficiencies in the experiment. Once the aspirin has been produced in the laboratory, its yield will be measured. Ethanoic anhydride is corrosive. This proves that the aspirin that had been made in the experiment was not 100% pure and contained some impurities. To prepare aspirin, salicylic acid is reacted with an excess of aceticanhydride. The reactants: In the experiment that was carried out the reactants were not measured by the apprentices. 4 0 obj Therefore precautions to chemicals such as Acetylsalicylic acid were taken as it is irritating to the eyes. Salicylic acid and acetic anhydride have heats of solvation in water, so aqueous catalyst would change the reaction’s rate of temperature change relative to the non-aqueous catalyst even if the catalysts were equally effective. Calculate the yield. Add 10 mL of Beaker 2 +/- 100ml ? Therefore moles acetylsalicylic acid (aspirin) = 0. This is a substitution reaction where the alcohol group from salicylic acid reacts with ascetic anhydride to form an ester, (acetylsalicylic acid) which is commonly known as Aspirin. For example, in water, the solubility of aspirin increases as temperature increases. 20g of aspirin was produced. 7 g in a very small test tube. %PDF-1.5 4. Mass of beaker = 166. App. Student worksheets at foundation and higher level. 0. This might explain the large data spread. SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. The excess acetic acid will be quenched with, the addition of water. As a result it had to be assumed they were correct. 1944. ? After a minute, remove the flask from the water bath and add 20 mL of distilled water. Add a magnetic stirring bar to the flask and begin heating the mixture. Data: ? 3623 mol + 0. Then carefully filter the product using the filter paper and filtering equipment such as the vacuumed container. Information about your use of this site is shared with Google. Sorry, but downloading is forbidden on this website. Reagent B – Weigh 1.00 g of the crushed aspirin tablet into a 50 mL beaker. 5 +/- ml ? For the synthesis of aspirin, how do you calculate the percent yield if the reaction produces 4.70 grams of aspirin. ? This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. ? The lab coats were 75% of the length of the apprentice’s height. Very small test tube Reaction Equations: Salicylic acid + acetic anhydride –> acetylsalicylic acid + acetic acid (C7H6O3) + (C4H6O3) –> (C9H8O4) + (C2H4O2) References: ———————– [i] [ii] Chemicalland: Lifestyle. Wear a lab coat and use eye protection. At 37°C 1g of aspirin is soluble in 100g of water. ? Using these ideas it will be deduced as how the temperature of water affects the solubility of the Aspirin. 80 ml acetic anhydride ? Tie long hair back. 4-0. The reaction for the synthesis is given below. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Prolonged contact with acid catalyst in the presence of water can lead to regeneration of salicylic acid starting material and reduce acetylsalicylic acid yield. Place the test tube in the melting point apparatus checker. Nomenclature List with Units m = Mass (measured in grams) n = Number of Moles (Mol) Mr = relative molecular mass Mol = Number of moles Apparatus: ? Apply knowledge in context and assess learning with questions exploring condensation polymerisation, including polyesters and the nylon rope trick experiment. Mass of wet product with beaker = 253. The reactant that runs out first is called the limiting reagent. As soon as a reactant is consumed the reaction will stop, no matter how much of the other reactants remaining. ), The Secret Science of Solving Crossword Puzzles, Racist Phrases to Remove From Your Mental Lexicon. 8 g ? Turn on the heater ? After 30 minutes of heating leave the flask standing to cool to about 50 degrees. Indus. The melting point of the Acetylsalicylic acid (Aspirin) was found to be 121°C according to the experiment carried out. Make sure while heating, in equal intervals agitate the mixture carefully to ensure the sulphuric acid is dispersed. ? The BF3ŸOEt2, due to its toxicity, was added by the TA. <>>> Chem. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. If there were any spillages they were noted to the lab technician. Then a comparison will be made between the experiments carried out in the laboratory and how the production of aspirin is carried out in industry. Aspirin or ASA (acetylsalicylic acid) can be synthesized by turning the hydroxyl group of salicylic acid into an ester group (R-OH → R-OCOCH 3) In the body, however, aspirin is again metabolized to salicylic acid, which is the active ingredient; The product can be tested for purity, by adding ferric chloride to an aqueous solution. The synthesis reaction of aspirin is shown below: The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form ofsalicylic acid (salicylate ion) to give a purple solution. Iodide ions infiltrate the helical chain of long starch molecules, turning the solution dark purple/black in the presence of amylose2. °C ? If you need this or any other sample, we can send it to you via email. Heat the water bath to boiling and keep it at this temperature for around 10 minutes, Add 2ml of distilled water to destroy remaining acetic anhydride. ? As the reaction had taken place there was no possible way of knowing whether the complete reaction had taken place or whether it was partially complete. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. ? Packaging (in industry) Conclusion and Recommendations Overall the experiment was a success, considering the flaws in the experiment such as the apparatus and time. This site uses cookies from Google and other third parties to deliver its services, to personalise adverts and to analyse traffic. Therefore specific safety measures were taken. (2008). To test for the presence of starch, iodine solution was added. Temperature measures in degrees Celsius Results: The mass of salicylic acid that was provided was 50g. ? As the solution cools, crystals of aspirin will appear. Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid. 3. Use a precise heating apparatus that gives heat up to a certain degree. Today, Americans spend about $2 billion a year for non-prescription pain relievers.

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