on Basically, PSA velocity is the rate at which your PSA level increases from year to year. The worksheet contains a list of what you need to use this prediction tool. What is a percent-free prostate-specific antigen test? Malecare is the world's leading men's cancer support and advocacy nonprofit organization. Read more. Of the 5,519 men in the placebo arm, PSA velocity usage would have led to 548 (almost 10% of the study population) additional biopsies, 433 (79%) of which would have been negative. Call us to schedule an appointment or contact us online. 2014). The calculator can be used by going to: This tool predicts the changes in PSA levels over time. The prostate-specific antigen (PSA) velocity is not a separate test. Reviewed The prediction tools are not to be used as a substitute for medical advice, diagnosis, or treatment of any health condition or problem. In using the prediction tools, you agree that neither MSKCC nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented in the prediction tools. Alternately, if at least three PSA values are available, enter all PSA values after receiving radical prostatectomy, beginning with the lowest PSA value. For the purposes of the STAMPEDE trial, a unique threshold PSA value for biochemical failure is calculated for each patient, referred to as the PSA progression value. From: This tool does not provide medical advice. 04/10/2008 PSA .05 PSA velocity can be calculated as change from the first PSA reading, standardized as PSA change per month. Please find the source code for the tool presented in: "Prostate-Specific Antigen Velocity is an important Prostate Cancer predictive marker in a prospective PSA based screening study". The most important values to enter are the date/PSA value for each PSA measured over the last 12 months. We hope with the launch of this calculator it will be easier for you to track a patient’s PSA record and progression status. Current recommendations for the use of PSA velocity include collection of PSA levels over a period of no less than 18 months and the use of multiple values (minimum of 3) to perform the calculation. It is not a separate blood test that a man needs to have. (Christos Mikropoulos et al. With PSA velocity, what matters is a significant change over time, and for this to be accurate, you need to have multiple PSA measurements taken in the same laboratory, because PSA measurements can vary slightly from lab to lab. See MSKCC does not assume any risk whatsoever for your use of the prediction tools or the information contained herein. The PSA velocity measures the rate at which PSA values change over a period of time, with any change greater than 0.75 ng/mL per mL per year being of concern. Please use this alongside the protocol to ascertain the patient’s eligibility into individual comparisons and the Biomarker Screening Pilot. While a change in PSA over time is often considered to be of greater concern than the absolute level of PSA, the role of this test in screening for prostate cancer is still uncertain. Memorial Sloan Kettering Hospital publishes, on the web, a prostate cancer calculator that among other things can calculate PSA doubling time and PSA velocity. If patients have already started ADT prior to randomisation, the first LHRH injection must have been given within 12 weeks prior to randomisation in order to be eligible for the STAMPEDE trial. In the past, research staff have received Progression Letters or contacted the STAMPEDE trial team to obtain this value. Using these data, Vickers and his colleagues calculated PSA velocity and estimated its sensitivity and specificity for prostate cancer detection. WebMD does not provide medical advice, diagnosis or treatment. PSA velocity is the change in PSA levels over time. http://www.mskcc.org/applications/nomograms/Prostate/PsaDoublingTime.aspx, For example, if you use my current PSA numbers which are: Copyright 1999-2020 Malecare, Inc | All Rights Reserved. PSA Velocity - Shiny App. Save my name, email, and website in this browser for the next time I comment. MSKCC does not endorse or claim validity for the prediction tools found on the MSKCC Web site. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Laura J. Martin Use of the prediction tools does not create an express or implied physician-patient relationship. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. by This tool can be used to calculate the rate of rise of PSA, expressed as the velocity in nanograms/mL/year, or the PSA doubling time, in months or years. The activities and products of MSKCC and its developers and agents (collectively MSKCC) are not endorsed by our past, present, or future employers. “PSA Levels & PSA Velocity (Doubling Time) Is Predictive of Your Survival Time” and June 6, 2007 “Biochemical Failure, PSADT and Morbidity Rates.”. 1999 May 5;281(17):1591-7. (Christos Mikropoulos et al. The calculator will tell you that my doubling time is now 4.24 months (0.35 years) with a velocity of 0.01 ng/mL/mo (0.14 ng/ml/yr). The level of change depends on your PSA number. To learn more, visit our Frequently Asked Questions. PMID: 10235151. MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. To learn more about PSADT and PSAV read my posts of February 3, 2008 If you think you may have a medical emergency, immediately call your doctor or dial 911. It will now take values generated by the ultra sensitive PSA tests. Prostate-Specific Antigen (PSA) Blood Test. © 2005 - 2019 WebMD LLC. Questions should be addressed to your own physician or other healthcare provider. From radiation therapy to clinical trials to check-ins with your doctor, your care is made as convenient as possible. Percentage of free PSA. Rather, it is the change in PSA levels over time. Even when the total PSA value isn't higher than 4, a high PSA velocity (an increase greater than 0.75 ng/mL in one year) suggests that cancer may be present and a biopsy should be considered. This tool can be used to calculate the rate of rise of PSA, expressed as the velocity in nanograms/mL/year, or the PSA doubling time, in months or years.

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